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Acute opioid-related disorders that necessitate medical attention include opioid intoxication, overdose, and withdrawal. Opioid agonist therapy (OAT), psychotherapy, and the treatment of acute pain in patients already on maintenance therapy are all issues related to the treatment of chronic opioid abuse.

Opioid addiction has been identified as a chronic disease distinguished by psychological and physical drug dependence, withdrawal, high susceptibility toward relapse, and high mortality. These side and adverse effects are the main reasons behind the limited use of highly effective opioids for relief from moderate to severe pain. Currently, the upregulation of the secondary cyclic AMP (cAMP) signaling pathway after chronic opioid exposure is most widely associated with the development of opioid addiction. In this chapter, we will briefly discuss well-accepted secondary cAMP signaling and new ideas that have helped in understanding this important pathway. We will then explore the role of cAMP signaling underlying the development of opioid dependence and assess its therapeutic implications for the treatment of opioid dependence and withdrawal. The chapter will finish with a discussion of how the cAMP signaling pathway can provide a highly potential drug target in the treatment strategy against opioid addiction.

Opioid addiction

has been identified as a chronic disease distinguished by psychological and physical drug dependence, withdrawal, high susceptibility toward relapse, and high mortality. These side and adverse effects are the main reasons behind the limited use of highly effective opioids for relief from moderate to severe pain. Currently, the upregulation of the secondary cyclic AMP (cAMP) signaling pathway after chronic opioid exposure is most widely associated with the development of opioid addiction. In this chapter, we will briefly discuss well-accepted secondary cAMP signaling and new ideas that have helped in understanding this important pathway. We will then explore the role of cAMP signaling underlying the development of opioid dependence and assess its therapeutic implications for the treatment of opioid dependence and withdrawal. The chapter will finish with a discussion of how the cAMP signaling pathway can provide a highly potential drug target in the treatment strategy against opioid addiction.

What Exactly Is Hydrocodone Addiction?

Hydrocodone is an opioid pain reliever that is typically prescribed to treat moderate to severe pain. Hydrocodone, unlike natural opioids Morphine and Codeine, is a semi-synthetic opioid. In general, doctors may decide to write a Hydrocodone (brand name Vicodin®) prescription to treat short-term pain after dental surgery or to treat pain caused by an injury. However, because Opioids are addictive, regular use of Hydrocodone can become habit-forming. When the body becomes dependent on Hydrocodone to feel normal, attempting to discontinue use will result in withdrawal symptoms. To alleviate withdrawal symptoms, individuals should seek treatment for their Hydrocodone addiction through detox and rehab. The risk of developing a chronic Hydrocodone addiction increases significantly after just five days of prescribed use.